Although cosmology is in principle sensitive to new high energy physics, such effects are typically suppressed to unobservable levels due to cosmic inflation. In this talk, I consider the potentially observable signal of Coleman-de Luccia bubble collisions during eternal inflation. The kinematics of two bubbles colliding can be solved analytically, which affects the survival probability of different vacua. For an observer undergoing a collision, isotropy is broken, with effects depending on the angle pointing towards the other bubble. Under some approximations, I analyze the effects on the cosmic microwave background, predicting that anomalous hot or cold spots as well as hemispherical power asymmetries can occur.